Anti-inflammatory Potential of Euphorbia helioscopia Extracts against RAW264.7 Macrophages

Pharmacognosy Research,2022,14,3,338-341.DOI:10.5530/pres.14.3.50Published:July 2022Type:Original ArticleAuthors:Iram Jan, Nusrit Iqbal Andrabi, Yassir Arfath, Tazeem Akram, Tusharika Kotra, Zabeer Ahmed, and Mithilesh Kumar Author(s) affiliations:Iram Jan1,*, Andrabi2,4, Arfath3,4, Akram2,4, Kotra3,4, Ahmed2,4, Kumar1,* 1School of Life Sciences, Jaipur National University, Jaipur, Rajasthan, INDIA. 2Pharmacology Division, CSIR- Indian Institute Integrative Medicine, Canal Road Jammu, Jammu Kashmir, 3PK-PD Toxicology Formulation CSIR-Indian Road, 4Academy Scientific Innovative Research (AcSIR), Ghaziabad, Abstract:Background: Euphorbia helioscopia, commonly known as sun spurge, is one the largest species an annual herb in family Euphorbiaceae, which extensively distributed worldwide. In folk medicine, it used to treat various ailments such malaria, osteomyelitis, gastrointestinal ailments. The anti-inflammatory potential helioscopia extracts on LPS-stimulated RAW264.7 macrophages was investigated this work. Results: ethanol extract found markedly inhibit pro-inflammatory cytokines (IL-6 TNFα) production compared aqueous treated cells. Moreover, downregulated nitric oxide levels. Finally, study, we have shown that exerts a potent pharmacological effect reducing inflammatory response macrophages. Conclusion: results experiment revealed study characteristics, with ethanolic having most. had strongest impact terms greatest reduction proinflammatory indicators including IL-6, TNF-, NO. Keywords:Anti-inflammatory, ELISA, TNF-αView:PDF (278.11 KB)